For sure; unless your group loves playing out combat scenarios that take the majority of the gameplay session, using a large number of mooks might be counter productive. It also comes down to prep-work, at least in part; you can pre-roll a whole page of dice and just scratch them off as you need them (one of my favourite ways to not have to roll a ton of dice constantly), or you can handwave a lot of rolls based on probability. A PR1 or 2 ganger rolling 8 dice on the attack is on average scoring 2.67 hits, while a runner rolling 10 dice on defense will score on average 3.33 hits. So on average, the mook is missing, and you can safely just skip a few rolls to keep combat moving by narrating the 4-5 mooks firing their weapons ineffectually and the player characters simply laughing or shrugging their attacks off.
I personally find incredibly detailed stats to be somewhat of a drag where the opposition is concerned, unless we're talking named NPCs. If I'm throwing my players up against a pack of devil rats I'm just not rolling 30 attacks; it's in neither mine nor my players interest for the vast majority of cases. I'll often just note down the kind of dice pools I expect enemies in an encounter to have (combat, social, resistance) both for my own sanity and for the flow of gameplay. But when the street sam goes up against the teams arch-nemesis in one-on-one combat, or when the enemy magician has summoned a particularly powerful spirit, or when the enemy shadowrunner rigger tries to pull a stunt to catch up to the players I roll it out using the specific stats of that character, because it adds drama and tension and excitement.
I've had a chance to go through the NPCs in Lockdown a little more in detail now, and some of them are really cool. The named NPCs can add a lot of flavor, but like the PR1 through 4 mooks/grunts in the core book the lower end of the spectrum are generally the same excepting those with special abilities like headcases. I would definitely use the CFD rules where appropriate, and use specific gear that may be lower-end to represent the desperation of people fighting in the Quarantine, but other than that they're just generic statlines as far as I'm concerned.