Hey!
I GMed a long zombie-apoc campaign in SR5 and it has been incredibly fun. It was very heavy, Seattle got slowly devastated and under quarantene. More akin to 28 days after than other staples.
It was a blast: you could still play regular stuff (matrix was still on) and PCs decided to go for a "management" kinda campaign in the final branch, re-starting a small community while going out from the "bunker" for a bunch of foucsed runs.
I used the Vampire Virus as the main issue, with tons of side plottings and a huge conspiracy behind the apoc itself.
Definitely works. Runs feel even more dangerous and the "tech-horror" feel was definitely fun.
