Two fo the three greatest campaigns I ever saw (Well, I ran one) were set in the SCIRE.
The other was set in Indonesia. If you've ever seen "CAN YOU TRUST VOODOO-MAN??? NO!!!!!!!"—It was that campaign. One PC was involved in all three, and the Wetar run was by far the most disturbing to him after he and a runner team joined with a bunch of shapeshifters had to unleash a hail of constant gunfire on an army of 2,000+ shedim while an elven mystic adept with more karma than God was getting his ass kicked by an NPC with hellacious propensity for Divination. Can you imagine the effect of seeing a bunch of badass tiger shapeshifters get torn apart by men, women and childen who just won't die? Oh yeah. There were a couple Master Shedim there, too.
And now it's all gone ... Damn.
Wetar was cool. I still prefer the SCIRE, though. I never got the chance (or had enough players) to really go batshit.
Anyway, let me think ...
The Briefing Room: Owned by and patronized mainly by ex-UCAS specfor. Anyone with a military background was welcome. Posers ... Weren't.
God's Descent: Famous for the mirror behind the bar running the length of the bar's space. Downtown location and a popular runner hangout before the SCIRE shutdown.
Golgotha: Downtown bar. It was as dark and foreboding as one might suspect. A hangout for Col. Lloyd Ritter when he was a Seattle runner.
Scarlet Veil: Was the hottest club in the sprawl until the original owner took off ahead of the feds, and took all of his extensive security with him. Once new owners re-opened it the Vory attacked and blew it up to kill four smugglers inside.
Biohazard: The hottest club in Bellevue, and some say Seattle. Owned by "retired" fixer A'Ja Rose.
Sick Haxx: Top half is for deckers. Bottom for mercs and street sams. The entrance is a zero-zone, but it's a good place to meet people you want to know.
Damn Good Coffee: Auburn coffeeshop. Jill the Ever-Present Barista is a friendly enough girl. De facto office for Val, a reliable fixer.
Exotic Aromas: Coffee shop across from UW.
Bellevue Square: Nice mall. Once suffered an attack of hacked drones.
The Northwest Broiler: High end steak house. Used as a hangout for fixers and Messrs. Johnson, especially used to hold wakes for deceased patrons.
Leg's Guns: Leg (full name is Legolas' from LotR) is an old elf who looks it. No one knows his background or where he gets his goods, but they are solid and no one dares mess with him or dig too deeply.
The Hollow Point: Popular runner bar in the Puyallup Barrens. Music's extremely loud. Good beer. Ol' Dwight is a surly bartender who no one fucks with.
Phlegethon Ring (Dante's Inferno): See above.
Dominic's: Italian Restaurant. A popular Mafioso hangout in Tacoma.
The Odessa: Tacoma hotel run and occupied by the craziest and most dangerous Vory in the sprawl, viz. the ones who blew up the Veil.
The Crime Mall: The Crime Mall.
The Seattle Monorail System: A convenient way to get around. You may even see someone get gutted for being a bastard.
Federated-Boeing Field: Home of the Seattle Mariners and espionage spy games.
Bank of UCAS Building: 80 stories tall. The top half was blown up/off during the NR attacks.
500 Block of Southern Street (Puyallup): "Abandoned" tenement. Reconfigured by the squatter residents for their purposes. Seems to attract evildoers to try and harm the residents, but they are a tough lot who attract street-level superheroics from nearby low-tier runners.
Prometheus Nine: Slick-ass SOTA club. They hold an annual lock-in for 24 hours where anything and will happen.
The White Factory: A massive abandoned factory at the southern end of Puyallup (city). It seemed abandoned. It was actually built with several stories underground and bad shit was done or was conspired to be done here.
The Olympic Peninsula: Black Sands Security was based here. It's a security/merc company that's actually one rigger/decker and everything else is his toys, including anthroform black-armor-clad ninja commandos and Heimdall—a railgun on legs.
Kobe Terrace Park—including the Pagoda and Bamboo Glade: The Pagoda often served as a random encounter locale due to its popular soynoodle vending machines.
University of Washington Campus—including Emson Hall: Emson Hall is the home of the Thaumaturgy Department. UW in general is UW, creepy murders of ravens and all.
Oh, man. I wish I remembered more locations or backed them up or something.
EDIT: Now with descriptions!