Blue Rose, MijRai, you both make good points on subjectiveness, and the idea of the No True Scotsman fallacy.
The question seems to come down to player RP capacity, and GM time/attention capacity, plus the story/part of the world the GM is planning to start with.
This got turned on its head once in a game I was in. I finally got to check 'play a drake' off my bucket list. Another player was trying out the concept of a rigger paralyzed below the neck. We wound up being dumped in a jungle, minus most of our gear; the rigger was able to keep one anthro-drone that he usually used to interact with the world. It was useful having a massive predator on-call, while much time and effort was spent on just keeping the otherwise ordinary human rigger relevant.
Perhaps a good rule of thumb is that it shouldn't take most of nearly every session to work out how everyone doesn't get caught because of the same character's mere presence on the team?
There are a lot of ways a character's presence can become a liability. Heck, as runners, it's almost inevitable somebody is going to make very personal enemies with somebody rich and powerful. One person who's really ticked off a blood mage can bring the hammer down on the party's head a lot worse than a pixie.
