Its plain simple, according to 6WA. Izrael got gassed by Lybia. Lybia got nuked by Izrael. Most of the area is now scene for Desert wars. Mana Storm covered most of Jeruzalem, left only a few alive, and than murdered and cpsequently Shedim possesed Ibn Eisa declared great Jihad and the rest of the civilization got wiped out. Not to stand back, Aden razed Tehran to declare the Jihad canceled, killing maybe hundreds of thousands in the process. Saeder Krupp established heavy presence in the area, which led Heszaby to razing their HQ...just dont recall if it was in Dubai... Istanbul got heavily infested by Bugs, and when those hives were cleaned, Istanbul become Smuggler h(e)aven.
Imo i forgot the first Jihad, that happened during Eurowars, but i dont have this updated in memory for a while...