Cool idea; sex isn't something that comes up often in my games, but certain topics have come up and it seems that you've got a pretty solid basis. I'll try to add some of my own thoughts, and expand upon what I've experienced in our games. I'll start by saying that I think sex can be a topic that can throw some people off in ways you didn't expect, so I'd just advice caution regarding too much detail and/or the way a topic is broached.
That being said...
Experience at tableSexual preference; this one was pretty straight forward, I think, at least for me personally. Our players range from early 20s to early 30s, and I don't think anyone really batted an eye at the idea that one of the characters is gay and living with his boyfriend.
Based on the fluff I've read throughout editions, social liberties at least in this area seems to have moved on significantly; you still have your hate groups, but at least according to Runner's Companion these seem to focus more on metahumans and certain ideologies than sexual preference. Should be pretty tame, unless someone at your table is uncomfortable with the subject, in which case a real-life issue could become an in-game issue.
Sexual assault; this one is definitely a whopper. Potential Season 2 missions spoiler ahead, you have been warned: during one of the missions in SRM02, the team discovers a "farm" where Ork women are being forced to carry implanted zygotes to term as part of some sort of diabolical Tamanous operation. This definitely threw some of my players off, and they still play up their characters hatred towards the ghouls who were running the operation.
Sexual assault, both physical and mental, and especially if magic is used, is to my mind something that has the potential to be incredibly shocking. It's definitely a mature subject, it's definitely a dark subject, and it's certainly something I wouldn't broach if I wasn't sure that my players were able to deal with it. That being said, this subject does have the potential to set up a truly villainous antagonist or group of antagonists, and in certain circles it could even be tolerated as "just a fact of life". Shadowrun is a dystopian setting, after all.
Own thoughts:Any sexual fetish you can think of (and a quick google search can probably give you some ideas you might not have considered

) that exists today is likely to have been accepted and commercialized in some way or another.
You already mentioned simsense, and this is a big one to my mind. Studios are creating "mainstream" porn these days that only 40-50 years ago was considered scandalous and completely taboo (doesn't mean people weren't doing it, just means it, whatever it was, wasn't accepted in society). Take pretty much any fetish that's considered "edgy" today (again, google is your friend, because this varies greatly by country and even region, as San Francisco is certainly more liberal than say, Houston) and introduce it to your game as part of a storyline involving a simsense studio branching out from their normal operations, perhaps, and you have a good start.
What's weird in 2070?I have no freakin' clue, to be honest. Cross-metatype/sentient metacritter relationships seems to be accepted, but we had a chuckle at our table of how a sexual encounter between a pixie and a troll would work out.
Mojo throws a big 'ole monkey wrench into the "what is normal" thing, but don't forget Hot-Sim VR. Both have the possibility of making anything and everything we "know to be true today" to go all topsy-turvy. Essentially, take any modern day sexual activity and/or fetish, add a sprinkling of magic or matrix enhancement, slow cook for 30 minutes, and presty; weird, freaky stuff.
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By all accounts, SURGE Level 3 and sapient metavariants are still pretty rare; I'm sure you could think of something involving the more extreme modifications that would be considered odd, if not taboo, in the seedier parts of town.
Also, bunraku parlors. While having another human being surgically altered to look like your favourite sim star and have a chip implanted in the subj... victims brain is "acceptable" by the fringes of society, it's still seems pretty vile and somewhat shocking to my mind. Something I'm sure a crafty GM could run with...
Also,
this topicThanks for broaching a mature subject in a meaningful way; I look forward to seeing where this discussion goes (fingers crossed!)