Fluff-wise, the penalties for augmentations are subtle - if you want to play someone who is messed up from implants, that is what all of the aforementioned negative qualities are for. But if that is your approach, go beyond merely taking some negative qualities or playing your character as an automaton, or a sociopath. Think about how the individual components could affect him.
His cybereyes could give a slightly unreal cast to his vision - his life is like watching a trid show; there is a distancing effect. His wired reflexes could make him frustrated with all of these slow, plodding people who are always getting in his way. His mnemonic enhancer could be a mixed blessing as he relives past violent encounters in too-vivid detail.