If you prefer magic and combat, then 5th will most likely be the one you will prefer in the long run. Yeah, direct spells to a major hit, but between Edge, Witness my Hate, and reagents you can raise the damage significantly. Sadly, the whole Artificing group is borked.
For combat, only one armor type (2 technically if you add in hardened) for players. You only get one attack per pass (can have multiple if you split your attack pool to attack multiple targets). This with overall damage increase (especially to melee weapons) has made in some ways combat deadlier than previous editions. One punch Adept builds have sadly taken a major hit, with Critical Strike not having ranks (but can be applied to any melee weapon skill) so only +1 to dv. Like pervious versions, bio-adepts are still the best setup in the long run. While skills now go to 12(13 with PQ) I have heard dice pools are generally not as big, due to bonus dice being rarer.
4th doesn't have Deckers, and that shit ain't right. Sadly, Data Trails brought back comlink hacking (via upgrades) and that is sad. Also, the matrix needs some love, fluff and some rules wise, and most decks are way to damn expensive. Your Runners will get paid better to hunt Deckers and hawk their decks.
Did I mention pay amounts (both Nueyen and Karma) are way borked? No, they are, but this can be fixed during play. By borked, I mean, it generally is to low for costs of upgrading gear, skills, or stats.
Oh, and Technomancers need lots of love and house rules, to be effective.