The results so far. 556 responses so far and I am keeping it open since people are still responding.
Quick summary is that setting is obviously far more important than the mechanics .. but the mechanics need to work well (well duh .. I didn't need this survey to tell me that

)
Explanation of what I am using as a standard then.
4.5 or higher = sacred ground (don't mess with it in anyway)
4.0-4.49 = very significant (better have a damn good reason for anything more than a superficial minor change)
3.50-3.99 = fairly important (better keep the basics in tact or else)
3.00-3.49 = good stuff (don't let it go away but some change isn't bad)
2.99 and below = insignificant
Mechanics(0) vs. Setting(100): 68
Survey Questions (1-not a factor to 5-very important)
D6 System: 3.26
Rolling large pools of dice: 2.82
Attribute + Skill: 3.67
Individual hits per dice (as opposed to sum total of dice): 3.24
Glitches and critical glitches: 3.38
Simple tests: 3.44
Opposed tests: 3.71
Specifically- Attack vs Defense: 3.26
Extended tests: 2.94
Teamwork tests: 3.15
Multiple detailed attributes: 3.83
Special Attributes: 3.94
Specifically-Edge: 3.52
Soak rolls: 3.13
Condition monitor/wound levels: 3.77
Separate physical and stun damage tracks: 3.69
Simplified skills: 3.24
Detailed skills and options: 3.49
Multiple pass initiative: 3.32
Flexible character generation: 4.60
Detailed gear options: 4.15
Flexible/open magic system: 4.29
Unified game clock: 4.09
Detailed combat and tactic options: 3.85
Fantasypunk setting: 4.70
Dystopian future: 4.45
Corporate intrigue: 4.49
SINless masses: 4.14
Magic: 4.37
Spirits: 3.88
Adepts: 3.88
Metahuman races and variants: 4.49
Awakened Politics: 3.87
Cyber/Bio ware: 4.71
Matrix: 4.47
Technomancers: 3.05
Riggers: 4.13