Wasn't Reagents in Spellcasting a limit-mod only in 5e, and in 4e all they helped you do was craft and certain rituals? So not that surprised they don't do anything for normal spellcasting now, since limits are gone.
Boosted Defense: "1 meter per dram of reagents spent", so own choice. (p143)
Rituals: "Must expend the amount of reagents specified for the ritual", & "For every dram of pure reagents spent (after the initial offering)" (p143), initial offering is nowhere described so I guess the base rituals in core don't require reagents?
Summoning/banishing: "spend reagents equal to the Force" (p147)
Preparations: "by the number of drams employed", so own choice, max 2 (p150)
Creating a focus: "The amount you need to spend" (p152)
Temporary Lodge: "by spending a number of drams of reagents equal to" (p153)