Just to close the loop on this...
When push came to shove, I was so busy trying to keep the mix of matrix and meat action going, I completely spaced on the Patrol IC. It rolled once and missed egregiously, the PC did a Brute Force operation to get the file in question pretty rapidly, took the Data Bomb and shrugged it off (with Edge reroll pulled 7 successes on the soak), and by the time I remembered I had planned to roll the Patrol IC every round the hack was over.
To add insult to injury, the rest of the group managed a combination of Physical Mask, team Con rolls, and Spirit Confusion power, so the poor guard never even got to shoot or or hit his big red "launch the defensive drones" button. When the group triggered the silent alarm and the boss called to ask what's going on, they immediately hacked the guard's commlink, rejected the incoming call, and put the boss on his block list. I expect the poor guy will be out of a job tomorrow, but hey, as a solo guard vs. a team of shadowrunners, it could have been a lot worse.
Next run, the real base will need to be defended by on-site forces instead of the concerned boss calling for backup that arrives too late to matter.

For a first session with a bunch of brand new players, though, we covered all the basics except drones and a gunfight, so it was a success in that regard.