Yes and no. There are some useful pieces of nanoware. Never install a nanohive directly; you want to get a partial cyberlimb (hand, foot, lower leg, or lower arm - not your mainhand arm) and put a nanohive in that. There are several types of useful nanites:
Universal Nantidotes are as close as you can get to toxin immunity. Toxins are nasty so this is good.
Learning Stimulus nanites are nifty. Start with a whole bunch of Knowledge and Language skills at rating 1, then use LS to bump them up to 3 for free.
Limbic and Neocortical are useful if you have noncombat Intuition or Logic (respectively) skills you care about.
O-Cells are like Universal Nantidotes, but disease rather than poison. Disease tends to be much rarer and there's other options to treat it, but this deserves mention because if your GM runs the infection rules for HMHVV as (very, very badly) written, this is the only thing that will keep you alive if you so much as touch a ghoul.
However, nanoware is not a substitute for another type of ware. It does nifty tricks, but it doesn't make you better at your core skills. You can't get Nanoware "instead of" other stuff, you can, however, benefit from getting it in addition to other stuff.
One catch - they aren't crazy expensive, but nanohives have 5xRating availability. If you want more than 2 types of nanites, you should wait for a good nanohive after chargen.