I'll be honest, and say that if your players are still new to the system, and you're a rookie GM, then the Artifacts campaign might be shooting a little high. That is a complex piece of work, and there are pitfalls where everything can go horribly wrong if they aren't handled just right every few pages or so, it seems. My advice? Hold on to the Artifacts books, and run some Missions to start off. They're easier on both GM and players, and they'll also help your players get used to the system and advance their characters a bit before getting faced with things like swarms of feral ghouls in the middle of a place that can only be charitably called 'Hell on Earth', or the fun and games of bringing high level magic things through Chicago. Just sayin'.