Well, the longest that I have had a game last was 3.5 years, playing twice a week for about 6 to 8 hours a game. By the end of it, I think the only original surviving character had close to 2500 karma. (which made intergrating the "newbies" an interesting event to say the least).... But as a standing hose rule, a retired character is worth 75% of his earned Karma and a dead character is worth 50% or earned karma....
But then again I run open ended campaigns that last as long as there is interest in them lasting (I am good with coming up with plot hooks, missions, red herrings, twists, turns, backstabs, feints and ideas to keep even the longest game fresh)... Sometimes Shit happens and a PC dies. Sometimes I have to make an example and KILL a PC..... but I never plan out a TPK... the odds are just too stacked in my favor to do so. It cheapens the efforts and work done by the players with their characters.
that said: Everything else is up for grabs. Contacts, equipment, homes, wives, girlfriends, children.... they all can/do feel my wraith WHEN the players earn such tactics.