So, inspired by a certain TV series (you'll either recognize it or you won't, I won't be more specific so as to avoid spoilers), I've been toying with the idea of putting the player characters in a fairly helpless position (in a well-respected meet location that does not permit anyone to bring in weapons, which would normally be safe-ish for meets) where they believe they are safe, then having one of the bad guys (with whom they're trying to make peace) turn on them and try to kill them all. It'd involve either a hostile takeover or blackmail or bribe or something for the owner of the meeting location, something that'd make it worth destroying their reputation as a safe meeting spot.
Then, once everything seems calmest, the bad guys reveal that their guns have not been taken from them, and they go in all-out murder mode. Full-auto suppresion fire, Powerballs, grenades, Spirit engulfment, the works. The team's mage and/or adept might survive, but anyone who depends on guns or their military armor will be pretty well frakked.
The goal of this will be to make an enemy that the players will be driven to want to flat-out destroy, whether they're being hired to or not. Make them self-motivated to accomplish a specific goal for themselves. To help offset any hurt feelings from the PKing, I would give the characters rolled to replace the killed ones some sort of bonus (starting with an extra 60 Karma during chargen, possibly), on the condition that the new character is someone who had a connection to one of the killed characters, who would be motivated to seek revenge.
I don't have any specific questions for the board here, just putting it forward for some general input.