I am trying to choose a setting for an upcoming game that is NOT set in Seattle. Since some of the players will be new to SR, having at least North American city may help however.
What I am looking for is a starting point that will offer a variety of settings and groups for potential runs while giving the players that are experienced and have run Seattle to death a chance for something different. I would prefer to use a source not older than 4e if I can help it, but if I get a great recommendation I might look at a 3e source.
So any settings you have run that worked particularly well (and briefly why)?
Also, I know not all setting books are created equal, so before I drop the coin on another, are there any you have found really well laid out/informative/deep or just the opposite?