Roadtrip!

Depending how much time you want to take in gameplay, here are a few ideas (I do tend to get off track in my games, but the journey is the fun part a lot of times):
*Depending how they are traveling (ground, air etc.) many para-critters can come into play - Nest of Thunderbirds can be fun
*Rogue spirit/elementals -- or possibly a wacked out hermit shaman that feels it's "their road"
*Broken down vehicle along side of the road - imagine the paranoia you could create, nice elderly couple having trouble in the middle of nowhere....maybe they really are just what the seem; doesn't always have to be a combat scene! Might be an eccentric corp VP who appreciates your help and remembers you a few runs from now. Feels they owe you a solid and pulls your hoop out of the fire.
*More light-hearted -- hippy meta-human commune
*Run across an insect spirit nest/hive
*Vehicle breakdown - aka lost in the wilderness scenario - keep in mind, a good number of runners are hardened veterans...in an urban setting. Set them out in the wilds over-night and play it up. They'll be in a fetal-position by morning!

*Mysterious deserted town -- could be a sub-plot of some sort
*Mistaken identity - one smuggler group thinks your runners is part of another smuggler group
*Sidejob - they have a side job dropping off a package for one of their contacts; end up in a run and gun through some unusual place - narrow canyons, old scrapyard, abandoned mines etc.
*Corporate test site -- testing beta <fill in the blank corporate badness> (ideas: drones, genetically modified creatures, biologicals etc.)
*Rural combat biking tournament looking for a team of players - top prize a custom bike!

*Variant of corporate test site - ground zero nuclear test - this would be a play up the stress, ending with the nuke not going off due to nuclear weapon instabilities (which is why the corp is testing)
*Astral rifts or astral mana storm - I know, it's not the outback, but you could go with a freakish one off storm in a localized area
Ultimately, you might check with your players to see if they want some side-run excitement or just a "time passes" we get there. I sometimes try to do to much to make it fun for them and ultimately they just want to get the current run they are working on and get paid! LOL!