@Herr Brackhaus: Okay, good to know about those changes. I knew 5E had increased both damage values and armour values (looking through the 5E Core PDF and Gun Heaven 3 shows that much), and I knew about the caps in 5E, which I actually do like. Just didn't realize the jump in the difference between starting hit caps and armour values was as wide as that. Same with trying to go for the one-shot-one-headshot build, seems like that's a lot harder to achieve in 5E. Not entirely sure how I feel about that yet, I'll probably have to play a few games in 5E to get a feel for it before I decide. But glad to know the changes either way, so thanks.
@Lucean: You're completely right about the special ammo creating the possibility for further issues. If a Runner carries ADPS cop-killer rounds, they need to make damn sure they don't use them anywhere they're seen or on camera (or take steps to delete said footage), or use them in a gun and with an outfot/gear that they promptly bury in a chest under a tree stump when not on a job. The point I tried to make is that there are ways to make pistols efficient, deadly, and viable as a main weapon, but it requires getting pretty specialized, abd potentially covering your ass better. But yeah, valid argument about the ammo.