Hhm well, there are several different roads that would lead to the "uplifted dog" goal. Listed in no particular order.
Loup-garou infected, more like the wolfman, and probably neither viable nor close enough to the concept.
Changeling with fur, fangs, tail etc. also too far away from the concept I recon
Mystic adept/hermetic mage with the shapechange spell and some nasty negative quality like extreme phobia common "own metahuman form"

E-mongrel technocritter. Run faster from 4thed had "technomancer" animals. No rules for these as player characters though.
CFD infected labrador. The CFD nano-virus can also infect normal critters with an AI mind. Again this needs heavy houserules to work.
Shapeshifter canine- most likely your closest bet, without going to much into houserule territory with the E-mongrel or CFD labrador.
sum2ten
C (2) canine shapeshifter
E(0) talent
B(3) resources
B(3) skills
C (2) attributes
The dog would need to use some of its specil attribute points to increase its magic score, if its gonna get some augmentations.
the labradecker could easily take some negative quality limiting its ability to go into metahuman form. And it would most likely take some other qualities representing its CRAZY background history.
Are you looking for valid builds? or are you looking into houserule territory? ie technocritters and CFD infected dogs as player races?