The archetypes in the book are what I would consider to be Prime Runners and do not represent normal opposition for the players.
Wait, what?! Sorry, but no. A Prime Runner is one that is MUCH more skilled than that. Prime Runners are experienced to the point where characters on par with the Professional Rating 6 NPCs are going to have a hard time.
"Grunts, no matter their Professional Rating, are nameless cannon fodder. They’re not meant to be remembered, whether they’re a match for the PCs or not. Prime runners, though, are different. They have names. They send the grunts out on their errands. They have their own plans and agendas. Most importantly, they move the plot along. “Prime runner” is a catch-all term. They’re not all shadowrunners as such. They are, however, significant characters who recur over the course of the adventure, and frequently over the course of a campaign. If grunts are extras and supporting cast, then prime runners are the special guest stars. They can fall anywhere along the spectrum, from the chief antagonist all the way to the lifelong friend of one of the PCs, and all points in between.
BUILDING PRIME RUNNERS A prime runner shouldn’t be thrown together. Like player characters, they should be built from the ground up, using the Priority System (see Building a Shadowrunner, p. 62), and advanced with Karma. As you build them, keep in mind the strength the NPC should have in relation to the PCs. This will determine how much Karma you’ll need to spend on the prime runner (see the Prime Runner Creation and Advancement table below).
There are four levels of prime runners.
Inferior: These prime runners are generally outclassed by the PCs in a straight fight, but the PCs should be cautious just the same. They frequently have friends who might just outclass the PCs right back.
Equal: These guys are on the same level as the PCs. Many of them will be shadowrunners like the PCs, but some may be company men, government agents, or syndicate enforcers.
Superior: This guy is more than a match for any of the PCs on an individual basis, but he’d be in trouble if the team decided to take him on all at once. They’re not bound by the constraints on skills or gear that apply to starting characters.
Superhuman: Some guys you just don’t mess around with, because they can probably take on your entire team and have a reasonable expectation of success. Like Superior prime runners, they are not bound by the constraints on gear and skills that apply to starting player characters. They should not be encountered very often, and when they are, it should be especially memorable."