Beta, are you asking about
Seattle 2072 in hardback vs. PDF?
I have both and use both. I like the PDF for being easily searchable, so if I need to find every reference to the Finnegan family it's easy to do so. The maps aren't extensive - just high-level district maps - but they're decent. You can get all the same information from the maps that fans have put together, like the ones FasterN8 posted. I especially like
this one because it includes the old Lone Star security ratings from the
Seattle Sourcebook. (I usually handwave it that Knight-Errant treats things the same way, unless I have reason to believe otherwise.)
And to Reaver's point, I would say that
Seattle 2072 is 99% compatible with 5E. I suppose it should include the Ork Underground as a separate district now, but the vast majority of the rest is still applicable.