Well, lets calculate it through:
Your target has a Hermes Icon (R5) commlink and above average WIL, INT and BOD (3), while using only cold sim.
The link has a damage track of 11
The victim has 10 stun and 10 physical damage boxes, as well as 3 overflow
Let's say you have dared to cast Redundancy at level 6 (because a registered sprite gave you teamwork dice) and kept all successes: The commlink can now take 15 damage before it breaks.
Best case scenario, you manage to deal exactly that amount with your first attack.
You do 15 DV to his stun track, he resists with WIL+Firewall, averaging 3 successes
His stun track is filled and he is unconscious, while receiving 1 point of physical damage.
That leaves 9+4(overflow)
You now have to deliver at least 20, better 28 matrix damage with one hit.
Still pretty unlikely.
Data bomb method:
You have a cheap deck and use the usual tricks (smoke and mirrors, overclocking, modifications) to raise the Sleaze Attribute to 10 or more. Since you can try to set a databomb with as many files as you like, you are guaranteed to get one that has a rating 10 databomb on it.
On average this bomb will do 35 points of matrix damage.
Now swap out your program for biofeedback and puppeteer the icon of your target to access this file
He receives on average 32 damage after soak - bringing him to 1 overflow. Dumpshock will give him another two on average, pretty likely killing him.
That is still pretty hard to achieve. You'd need at least a R12 databomb to do enough damage against a more robust target.
Still, a starting character could pull it of.