Yeah, things to keep an eye on include...
Drone and vehicle speeds (a Bulldog's max speed is 40mph? There's a lot of problems with the ratings applied, if not the table itself).
Drone and vehicle durability (light pistols can shoot down 'combat drones' reliably).
Suggested income/karma for 'runners (far too low in my mind, when net income a year is 20k-30k, it means any nuyen-advanced characters will spend year after year trying to earn their next bit of 'ware while magic-types traipse on by).
Professional Rating discrepancies (6, 8, 11, 18, 20 dice pools).
Background Count's pervasiveness (by the descriptions and rules, it is everywhere, at all times, and all magic users constantly take penalties unless they spend the 10-20 karma to acclimate).
Certain Run & Gun actions (looking at you, Bull's Eye Double-Tap).
Adept Ways (horribly edited, way over-priced).
Metavariants/Metasapients have a rather large number of flaws (costs, abilities, etc.)
The list goes on, these are just some of the more egregious problems in my mind.