I've been living in the San Francisco Bay area for a little more than six years now. So my campaign runs in the "San Francisco Bay Metroploitan Zone" which covers the San Francisco Sprawl, the Oakland Sprawl, and the San Jose Sprawl (with a bunch of subsprawls like Diablo Canyon, Marin, Hayward/Fremont, and the little stretch of sprawl from San Bruno south to Palo Alto).
With three sprawls sort of interlinked, it makes it easy to showcase the entire strata of life in the 2070s. I also get to add the aftermath of the IJS occupation, and border tensions with Tir Tairngire. So far my runners have been focuses primarily on activities in Oakland, with a couple of small runs into San Jose.
Hopefully I'll sieze the opportunity to send them into San Quentin Prison for a nice visit with the really hard fraggers locked up in there.