I'm not aware of any RAW guidance on what all still "works" after a Shapechange spell. Cyberware, Bioware, Geneware, Drugs, Physical Adept powers, Sustained Spells... ect ect.
I mean, really, who doesn't want to play a chameleon skinned 'Gator hopped up on Kamikaze with a magic set of chompers. And what does happen to the Troll Face's Pheromones, or the Samurai's Tetrochromatic eyeballs when you turn them into a Horse?
I can see RAI in game arguments for Adept Powers, Sustained spells, but drugs, nanotech, geneware... eh.. bioware and Cyberware okay, not so much. But is there any RAW other than "...not transform clothing and equipment." Is a Superthyroid gland Equipment? Or Synaptic Acceleration?
Anyway... I get that Shapechange is a basically 101 GM calls as to what works and what doesn't. Looking for something RAW for basic guidance, failing that, I'll take any random internet ramblings under consideration.