Unwired is the hardest call. A group without a matrix specialist is at a huge disadvantage.
Well, the group is only going to be 2 players--I've had my fill of 6+ groups, and want to run a game with a smaller group. My conceit for the game, and for Running in general, is that various groups and individuals come together for a specific job, then go their seperate ways. So, I want my players to be the "generalists"/infiltration/assault team guys, while the driver, decker, sniper, etc. are NPC's. If/when the NPC's skills come up, I'll have the players roll/play them out, but in general the "support" roles will be NPC's.
Diffferent Runs will have different teams, and ideally the NPC's will be different enough that they players will form some kind of connection with them--even better if it's a rivalry or the like.
Of course, if a PC dies during a run, then they can play one of the NPC's. I'm not sure how I'll hand cases where the NPC choosen was planning on betraying the party the whole time--hopefully it'll come up rarely, if at all.
Basically, I'm inspired more by the film Ronin than, say, Ocean's 11 or Heist.
And yes, you can tell my lack of knowledge of the Cyberpunk genre by my constant citing of movie sources over books, and many of those movies aren't even close to being Cuberpunk stories...