Frankie gave an excellent list.
In general, Low Lifestyle neighborhoods aren't that horrible. The ACHE is little more than a prison, and somewhere outright radioactive/toxic is going to be a zero zone.
Low lifestyle neighborhoods are nicer than the typical "barrens" areas. Residents have SINs (at least fake ones), pay rent, eat regular meals(of processed food), and have basic services. There is a rent-a-cop that patrols your apartment building, and there is a garage or at least a lot with security to park your vehicle. And while you certainly want to keep your wits about you, the grid guide works, and if someone is walking around with assault weapons Knight Errant shows up with a swat van. There are going to be inexpensive to moderate price restaurants, shops, and entertainment venues around. People in these neighborhoods are semi-skilled or skill wire factory workers, service industry workers, students, retirees on a basic pension, etc. Also, petty but successful criminals and shadowrunners at the start of the career fall into this range.
