By the way, if you're a fan of his, make sure to watch Dr. Horrible's Singalong Blog. It's also got Neil Patrick Harris, in addition to some other funny, talented people.
http://www.drhorrible.com/
It's the best, funniest musical ever. I've seen it like three times.
Seen it. Laughed my ass off. Love it. <3
And I love Firefly to bits. Every part of it. River, Mal, and Kaylee are my favorites, but the whole damn crew just FIT together so well. I never have the patience to watch reruns, but I will sit and watch every single marathon SciFi does. And please don't compare it to Twilight. >_<!! None of you are adolescent/young adult girls. You cannot appreciate just how painfully HORRIBLE that scrap of writing is. If you're going to bash it bash it to like... Harry Potter or something. Just NOT Twilight.
And another "could be converted to shadowrun setting" that is also a crack addiction of mine is Repo! The Genetic Opera. Go see it. Seriously. TOTALLY AWESOME musical, this generation's Rocky Horror Picture show (though thankfully replacing all the damn sex with violence and comedic gore). LOVE IT.
Not to mention the writer for it, Terrance Zdunich, is one of the sweetest, most humble twisted and derranged psychopaths you will ever meet.

You can't be right in the head and write that kinda shit.