If you are getting Karma to spend on top of build points I strongly agree that you should buy your specalizations with Karma. At only 2 karma each they are a steal. Also, skills that you may only want one or two points in maybe save for the karma, cheaper that way.
The glorious thing about build points is that skills have the same cost per level at level 1 as they do as level 6. Karma advancement costs more as you go up. Get the big things with your build points. Is your GM holding you to the "1 skill at 6 and everything else at 4" rule? You really should be spending your build points on skills you want a 4 (or 6) in, and then spending the karma on the one pointers and the specializations.
Same thing with stats. Other than when you hit hard cap that first point of stats cost the same build points as the last point of stats. Its better to have a stat at 5 an buy a few of those skills with karma than to have a stat and 4 and some one point skills, especially if you are going to hit the first session with karma to spend.