Shadowrun, of course.
Call of Cthulhu(so far more of my characters have died than gone insane, but NONE of them have lived, and all told, I'm well over ten complete campaigns. When they die, I have to pick an NPC and join the others.
D&D 4e. Yes. I play. Yes, I run it too. Yes, I have a ball doing both. Not quite sure where the huge mass hatred of it comes from, but there is no doubt it is there. *shrug* Doesn't mean I don't like it! Particularly the Dark Sun setting.
Palladium(which includes Rifts, the fantasy, and Heroes. Probably more Rifts, but the supplements started getting crazy. At least with 4e D&D I can just update through the Char builder.
Rolemaster. C'mon. How many LOVE when they roll those 'special' numbers on the charts?
Star Wars Sagas. Not the d20 edition, but the d6 version.
Warhammer RPG though my characters die even faster in that than Cthulhu. Sick and wrong!
Original Vampire: the Masquerade. I possess many fond memories of my Ventrue accountant, and just haven't been able to bring myself to try the other versions(Maybe thus the resistance to 4e DnD? I dunno. I certainly have played ALL editions of D&D, and like 2nd e and on.
Traveller(though I can only ever find anyone else who plays it, at conventions.)