Aside from Shadowrun, I GM 7th Sea and CthulhuTech. I love the old d10 Alderac 7th Sea system and the setting is just simply too fun. My campaign's been running for at least 5 years now and I think it's hilarious that people remember plot points by the cinematic nonsense they pulled off during that part of the story...
CthulhuTech is still pretty new for us (I've run maybe half a dozen adventures), but it's gaining traction. The dice system takes a little getting used to, but I'm slowly getting a grip on what blend of anime and Cthulhu mu players are after.
I also love All Flesh and Dark Heresy at the moment, with Paranoia not far off. These I typically only get to play at conventions, but with a disposable character I have no qualms about playing balls-to-wall with them and if they get eaten/disintegrated/labeled a commie-mutant-traitor at least I took some of them with me.
Play WarMachine and 40K as well... my time is at a bit of premium, but thankfully my wife likes the games too, so I don't get in too much trouble for my past times.

Insomniac