if you have changed Shadowrun into a different game yourself.
Ran a pseudo-medieval horror game where the matrix was the base layer of the astral realm, cyber and bioware were parts you chopped off/made from extradimensional monsters or chopped out of horrific mergings of yourself and said monsters (Essence loss was call "corruption" in-milieu), and most of the game took place in the half-astral city that literally was the last bottleneck for those same beings. Everyone ended up crazy and dead. Not necessarily in that order.
I'm planning a sort of post-apocalypse-lite Googie/Indigenous decaying American Dream campaign for which I will use Shadowrun minus the cyberware and matrix. There will be dinosaurs, Nazis, UFOs, reptilian humanoids, atomic-nuclear shaman robots, art deco and Googie
everywhere, and the Uktena will try to eat people. There may also be roving bands of marauders who style themselves after greasers and fight with katanas. It's gonna be awesome.
Also, next time I run L5R, I will get a feel for characters, send them after a risen Fu-Leng, and then he will hurl the characters to a LAND WHERE EVIL IS LAW and I will hand everyone SR4 versions of their characters.
I love how modular everything is.
Also one day.

Everyone will make adepts with the geas "Ridiculous Outfit" and they will hunt down evil artifacts.
I WILL MAKE IT HAPPEN