Pittsburg is considered the midwest? I chalked it up to being in the Northeast, myself. Huh.
At any rate, I use Philly as my Shadowrun campaign city, but I've never seen anyone dabble in Pittsburg. I think the run-down nature of it, and the perceived lack of a future, has hampered it. It was an old indutrial town, but Shadowrun's industrial side has moved on.
Heck, Lofwyr and MCT probably own the place.