As others said, as Brainy there is an NPC, he has no problem with the usual limitations, but if you like to add in-universe coherence to that character, there could be some problems (and a bunch of paths for you to tread for solutions):
- Cyborgs in Shadowrun are usually unstable, since being just an isolated brain is really not a great life prospect and the process to maintain a fragile organ alive on it's own must be all but natural;
- A disembodied brain would usually be a poor 'mancer, cause being turned into a freaking brain in an aquarium does not work miracles on one's "holistic integrity" - i.e., a just-a-brain would have crappy essence, which would make him a bad technomancer - still, there's the precedence on Corporate Intrigue (which are not that great for what yoou have in mind);
Being exceptionally resilient, being an experiment which miraculously make it right (but which is not able to be replicated), being a result of some of the most bizarre SURGE case... all of them are possibilities in which your character could be explained to be as it is.