So you got characters, decently built and somewhat interesting.
You got a story: Fighting on behalf of a Green Policlub and handing out justice to those polluting the Bayou while something far more sinister lurks under the surface of this preamble.
You got free time, you got your dice and then....
You realize that you're playing the game with people that neither know, care, or desire to do either about the world of shadowrun. They want to shoot each other, grope guards, seduce hookers, cast orgy everywhere, make blood mages and Cyberzombies (After barely reading about them), and thinks a good way to deal with a corp is blowing up the local branch with enough high powered explosives to be labeled as terrorists by several governments.
So what do you do when you come across a playgroup that just doesn't fit or is hard to control. Especially when their direction they desire to go is far far far from where you are writing?