Penetrating strike isn't horrible, but it is only worth getting if you have already maxed out critical strike, which is significantly better. Without adept Ways, or martial arts, an adept unarmed combat specialist is relatively weak. I would recommend hard-maxing Magic, then getting the following bioware: synaptic booster: 2, muscle toner: 4 (with the restricted gear quality), reflex recorder for unarmed combat, and then either another reflex recorder (for a ranged skill) or a rating: 1 damage compensator. For your 4 points of powers, get killing hands, 4 points of critical strike, 2 points of improved ability in unarmed combat, and finally, either a point of combat sense, a point of counterstrike (good at level one for the ability; not really worth it past level: 1), 2 points of penetrating strike, or elemental strike.
Although this is a pricey build, you should still be sure to get a good ranged skill at rating: 4 with a specialization. The good thing is that high Agility and multiple initiative passes are good for ranged as well as close combat.
