Critical Strike works well enough to overcome the metaracial disparities, IMO. Sure, an Ork or Troll would always be a hair better (because they can take the same power), but depending on the power level of the game it's not like you'll be outright gimped or something; there are enough ways to get your Unarmed pool really high, and your Unarmed damage really high, that the odds are good you'll still be plenty capable.
The bigger problem, of course, is the general balance of melee vs. ranged combat. My advice? You'll need to make sure you've got (a) a way to get in close before you get shot full of holes, and (b) a fall-back plan. Be really fast, be really sneaky, be tremendous at dodging and/or soaking, be all of the above...but have a way to close the distance in one piece. At the same time, though, accept that melee combat isn't always the option, and you don't want to be dead weight to your group. Be able to fill in in a secondary role, and be able to still do something of value when the answer to the problem isn't "punch someone." Have a reasonable ranged combat skill, pull double-duty as a Face, just make sure you can do something besides Kung Fu, and stay a reasonably well-rounded shadowrunner (not a one-trick pony).