Joe Clifford Faust's book "Company Man" (which pretty clearly was an inspiration for early Shadowrun, giving us the terms "company man" and "dogbrains" as well as the firm Seretech, mentioned in the Secrets of Power trioogy) had the concept of the "pizza run". These are low-level disruption jobs, usually with significant restrictions on the level of violence and physical destruction permitted. In the book this involved things like the classic bogus pizza order prank; planting bogus but believable evidence of an individual having an affair where his wife could see it; vandalizing his car; and other measures designed to make the person's life a living hell, and thus slow up the R&D he was performing.
This is part of the whole spectrum of disruption jobs that can lead up to physical structure hits. For example, runners could be sent to damage or destroy a key piece of equipment at the Federated-Boeing metals plant in Tacoma that is about to start fabricating key components for a new line of drones. For a real challenge, make it so that the damage isn't permanent, or somehow engineered to look like incompetence on the part of the Boeing wageslaves.
Don't forget about diversions, where the runners' job is to attract attention and/or tie up enforcement resources while another group executes the real job. "We need you to tie up traffic for 25 minutes on the I5 south of exit 7. We don't care how you do it, but try not to kill anyone." A more evil-minded GM might give them one that looks like a normal job, but engineered somehow to go south, so that the runners don't know they're a diversion and thus whatever flailing they do on their own behalf works to further draw attention away from the priority effort.
EDIT: punctuation fixes.
