Skillwires replace your skill too, not add on to it, unless I have that wrong. The whole point is that those high numbers are HARD to get to, like to get +6 DP bonuses on the whole social skill group, it's 110 karma, to go the adept route, cyber is 24 Karma to just get a +5 bonus, that's with tailored pheromones, and enhanced pheromone receptors, and a 0.7 essence loss hit too.