Honestly? I would NOT do this as your first time at the DM's chair. Even when you're going from a system you know well, using stock modules, there's so many things that can go wrong, even for seasoned GMs. You're taking all of that, and making it even more complicated.
If you want to do a supers game, where the players are some of the first or few supers in the world, I'd suggest ditching the SR setting and rules entirely, and pick up something else. If you want a more comic book feel, then Mutants and Masterminds is a system tailor made for supers, and it is based on the d20 system, so your players likely know 90% of the 'in play' mechanics already. If you're looking for something more grim and gritty or tactical, you should try Hero System. Chargen is a nightmare without having something to do the math for you, but in play it is a very enjoyable system to work with, and provides a more tactical, rough and tumble style of combat, not unlike the feel of Shadowrun. And then there is always GURPS.