"Disposable" Sidearm
Colt Government 2066
Accessory (Top): Smartlink (Skinlinked)
Accessory (Barrel): Silencer
500 nuyen plus 650 in accessories. Carry this to meets, or just in shady areas. Not a running piece, not something you use to conceal. The silencer's disposable as well, so you can keep the skinlinked Smartlink accessory when you throw it away.
"Intimidator"
Savalette Guardian
Personalized Grip, Skinlink
Advanced Intimidator Option: Additional Clip, Chameleon Coating, Gecko Grip
So the 800 nuyen gun gets a simple personalized upgrade for 150 nuyen extra. It's a nice, obvious weapon that's quite loud.
The Advanced Intimidator doubles the clip size to 2x12c (giving you the option to select different types of ammo if you wish). And it can be attached on your person while cloaked. Extra recoil comp is unnecessary for the Guardian, bursts are complex actions anyways.
This is a deterrent weapon, if they're not dead they're running away by the sudden (and hopefully unexpected) firepower. You can apply the Chameleon Coating and Gecko Grip option for 1100 nuyen and 3 slots. I recommend it for when you're in areas where you won't get scanned but visible weapons are still prohibited (or at least frowned upon).
Stock Pistol
The HK Urban Fighter Heavy Pistol is a bit of a bargain, I try to acquire one for my more subtle (read: almost all) runners. Too bad it can't be further modified, though I always ask the GM if I can at least buy it with the Skinlink option. Being ceramic and hermetically sealed is nifty, but broadcasting your Smartlink system is just silly.
"Infiltrator"
Colt Government 2066
Accessory (Top): Smartlink (Skinlinked)
Accessory (Barrel): Silencer
Modifications: Chameleon Coating, Gecko Grip, Easy Breakdown, Additional Clip
3050 nuyen, similar to the disposable weapon above. With the accessories and whatnot you can break this down and stick it on yourself or other items. The accessories wouldn't have the chameleon or gecko modifications.
It's for when you need to bring a respectable amount of firepower discreetly and discretely inside a somewhat secure location. With the Colt Government 2066's electronic firing and your silencer, you won't bring attention to yourself (until they fire back at least).
It's excessive, but it's available at chargen if you can convince your GM. If you don't fancy the Additional Clip model, you can swap it out for the ceramic components mod.
Those are the standard handguns I usually give my runners. It gets pricey, but I do love the bang-bang.