Only vaguely related to the original question, but this seems to a place to mention something that is probably obvious to lots of people but was not obvious to me until I started playing around with the Priority and Karma systems. How you spend your attribute/adjustment/skill points makes a HUGE difference in how much Karma you have to spend to achieve a target value for an attribute.
To take a simple example, lets say you have 10 points, and want four attributes to be at 6, 5, 3, 3. If you spend the points 3, 3, 2, 2 you'll be at 4, 4, 3, 3. You'll need to spend 5*5+6*5+5*5 = 80 karma to get to your target, which is impossible. But if you spend your points 5, 4, 1, 0 you'll be at 6, 5, 2, 1. You only need to spend 3*5+2*5+3*5 = 40 karma; you achieve your target with points to spare.
Another way to think about this is that the effective Karma (eK) of an attribute/skill/adjustment point is much greater when spent to improve a higher attribute or skill than to improve a lower one. Spending a point to turn a 5 into a 6 is worth 6*5=30 eK, but spending a point to turn a 1 into a 2 is only 2*5 = 10 eK.
The rule of thumb seems to be spend your attribute/skill/adjustment points on the things you want to have the highest values in first, don't spread them around evenly. Rely on Karma to get the 1 or 2 extra points in low level things you need in the final stage. I would argue this isn't "min-maxíng" (assuming that is something you frown upon, which you may not), this is just acknowledging a basic emergent property of the character creation system.
Again, I am sure this is obvious to anyone who has played more recent editions of Shadowrun. But to a person like myself who last played back around 1991, or to a person who has never played before, this may not be obvious.